Slide 179.Cholangiocarcinoma, Liver

A. Brief Descriptions

  1. Less common than hepatocellular carcinoma

  2. No direct relationship with cirrhosis

  3. Resemble adenocarcinoma arising in the other part of the body.

  4. Rare bile stained.

B. Gross Findings


C. Micro Findings

  1. Clearly defined neoplastic glandular and tubular structures in portal area.

  2. Lined by anaplastic cuboid to low columnar epithelial cells.

  3. Markedly desmoplastic stroma.

D. Others:


E. Reference

  1. Robbins Pathologic Basis of Disease, 6th ed.  P.888-890.






Fig. 179-1 (LP)The hepatic parenchyma is infiltrated by irregular glandular or papillary structures. The normal liver is in the left.





Fig. 179-2 (LP)The irregular cancerous glands infiltrate in liver parenchyma.





Fig. 179-3 (LP)Marked stromal desmoplasia. The fibrotic tissue surrounds cancerous glands.




Fig. 179-4 (LP)The cancer cells form ill-defined or fused glandular structure.




Fig. 179-5 (LP)The hyperchromatic, pleomorphic cancer cells arrange in irregular glandular or cribriform patterns.