Slide 56.Pseudomembranous colitis, Colon

A. Brief Descriptions

  1. In patient had recent course of antibiotics intake.

  2. Caused by Clostridium difficile (a normal gut commensal) and toxin formation.

B. Gross Findings

  1. Characterized by formation of an adherent inflammatory exudate (pseudomembrane) overlying sites of mucosal injury.

C. Micro Findings

  1. The plaquelike adhesiion of fibrinopurulent-necrotic debris and mucus to damaged colonic mucosa.

  2. Supuficial crypts are distended and damaged with inflammatory infiltration.  

D. Others:


E. Reference

  1. Robbins Pathologic Basis of Disease, 6th ed.  P. 809 ~810.





Fig. 56-1 (LP)Superficial erosion of the mucosa and an adherent "pseudomembrane" of fibrin, mucus, and inflammatory debris. 



Fig. 56-2 (LP)Superficial crypts are distended and damaged with inflammatory infiltration.



Fig. 56-3 (HP)"Pseudomembrane" contains amorphous, eosinophilic, fibrin exudate with cellular debris and inflammatory infiltrates.