《Slide 64.》Mucoepidermoid Carcinoma , Salivary Gland

A. Brief Descriptions：

1. They are the most common form of malignant tumor primary in the salivary glands and are the most common radiation-induced neoplasm.

B. Gross Findings：

1. Apparently circumscribed, lack well-defined capsules with often infiltrating margins. 

C. Micro Findings ：

1. Presence of squamous cells , mucus-secreting cells, and cells of intermediate type.

2. The mucus-secreting cells are cuboid or goblet like. May form cysts, single layer lining of the cyst, irregular multilayered solid sheets, or irregular multilayered masses.

3. Epidermoid cells: also form solid masses or sheet, or line the cyst.

4. Intermediate cells have squamoid features with small to large mucus-filled vacuoles.

5. Stroma: fibrous connective tissue, or escape of mucus.

D. Others:

    　略.

E. Reference:

1. Robbins Pathologic Basis of Disease, 6^th ed.  P.772.

　

 

 

【 Fig. 64-1 (LP)】The tumor consists of mucin-containing cysts mixed with sheets of squamoid cells.

 

 

【 Fig. 64-2 (LP)】Presence of squamous cells , mucus-secreting cells, and cells of intermediate type.

　

 

【 Fig. 64-3 (LP)】The mucus-secreting cells are cuboid or goblet like. May form cysts, single layer lining of the cyst.

 

 

【 Fig. 64-4 (LP)】Squamoid cells form solid masses or sheet.

　

　

 

【 Fig. 64-5 (HP)】Intermediate cells have squamoid features with small to large mucus-filled vacuoles (in the lower field ).

　

 

【 Fig. 64-6 (HP)】Intercellular bridge in squamoid cells.

　

 

【 Fig. 64-7 (HP)】Mucin-secreting cells have tall columnar shape and contains mucin in the cytoplasm.