Slide 64.Mucoepidermoid Carcinoma , Salivary Gland

A. Brief Descriptions

  1. They are the most common form of malignant tumor primary in the salivary glands and are the most common radiation-induced neoplasm.

B. Gross Findings

  1. Apparently circumscribed, lack well-defined capsules with often infiltrating margins. 

C. Micro Findings

  1. Presence of squamous cells , mucus-secreting cells, and cells of intermediate type.

  2. The mucus-secreting cells are cuboid or goblet like. May form cysts, single layer lining of the cyst, irregular multilayered solid sheets, or irregular multilayered masses.

  3. Epidermoid cells: also form solid masses or sheet, or line the cyst.

  4. Intermediate cells have squamoid features with small to large mucus-filled vacuoles.

  5. Stroma: fibrous connective tissue, or escape of mucus.

D. Others:

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E. Reference:

  1. Robbins Pathologic Basis of Disease, 6th ed.  P.772.

 

 

 

Fig. 64-1 (LP)The tumor consists of mucin-containing cysts mixed with sheets of squamoid cells.

 

 

 

Fig. 64-2 (LP)Presence of squamous cells , mucus-secreting cells, and cells of intermediate type.

 

 

 

Fig. 64-3 (LP)The mucus-secreting cells are cuboid or goblet like. May form cysts, single layer lining of the cyst.

 

 

Fig. 64-4 (LP)Squamoid cells form solid masses or sheet.

 

 

 

Fig. 64-5 (HP)Intermediate cells have squamoid features with small to large mucus-filled vacuoles (in the lower field ).

 

 

Fig. 64-6 (HP)Intercellular bridge in squamoid cells.

 

 

Fig. 64-7 (HP)Mucin-secreting cells have tall columnar shape and contains mucin in the cytoplasm.