《Slide 67.》Adenocarcinoma (early gastric cancer), Stomach

A. Brief Descriptions：

1. A carcinoma limited to the mucosa or to the mucosa and submucosa only, irrespective of whether or not metastasis to lymph nodes has occurred.

2. Two groups: intramucosal and submucosal.

3. Not synonymous with carcinoma in situ.

B. Gross Findings：

1. In early gastric carcinoma, tumor in confined to the mucosa and submucosa and may exhibit an exophytic, flat or depressed, or excavated conformation.

C. Micro Findings：

1. In low power, there is an ulcer with regeneration.

2. Neoplastic glands in the edge of the ulcer with fibrinopurulent exudate and necrotic debris in the ulcer base.

3. Cancer cells in the edge of the ulcer with irregular arrangement and hyperchromatism.

D. Others:

  略.

E. Reference：

1. Robbins Pathologic Basis of Disease, 6^th ed.  P.798 ~ 802.

　

　

 

【 Fig. 67-1 (LP)】There in an ulcer with regeneration.

　

 

 

【 Fig. 67-2 (LP)】Ulcer with fibrinopurulent exudate and necrotic debris in the ulcer base.The neoplastic glands locate in the edge of ulcer and extending to the submucosa.

　

 

【 Fig. 67-3 (LP)】Neoplastic glands with complicated glandular structure.

　

 

 

【 Fig. 67-4 (LP)】Cribriform gland formation.

　

 

 

【 Fig. 67-5 (LP)】Neoplastic glands are lined by cells exhibiting pleomorphic, hyperchromatic nuclei with some distinct nucleoli.

　

 

【 Fig. 67-6 (LP)】Mitotic figures are occasional seen.