《Slide 141.》Bowen's disease, Skin

A. Brief Descriptions：

      1. Occur on exposed or on unexposed skin and in pigmented or poorly pigmented skin.

      2. Intraepidermal squamous cell carcinoma, squamous cell carcinoma in situ.

      3. Slightly elevated, scaly, flesh-colored plaque of long duration.

B. Gross Findings：

1. Slowly enlarging erythematous patch of sharp but irregular outline; within the patch are general areas of scaling and crusting

C. Micro Findings：

1. The epidermis is thickened.

2. The border between the epidermis and dermis appears sharp.

3. Throughout the epidermis, cells lie in complete disorder, and many of the them appear atypical, showing large, hyperchromatic nuclei.

4. In the epidermis there are scattered cells showing atypical individual cells’ keratinization (dyskeratosis).

5. The horny layer usually is thickened and consists largely of parakeratotic cells with atypical, hyperchromatic nuclei.

D. Others：

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E. Reference：

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【 Fig. 141-1 (4X)】

　

 

 

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【 Fig. 141-10 (40X)】