《Slide 95.》Retinoblastoma, Eye

A. Brief Descriptions：

1. The most common malignant eye tumor of childhood.

2. A cell of neuroepithelial origin in the retina.

3. Nodular masses often with satellite seeding.

4. Spontaneous regression: calcification and severe inflammation.

B. Gross Findings：

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C. Micro Findings：

1. Small round cells with large hyperchromatic nuclei and scanty cytoplasm

2. Flexner Wintersteiner resettes：

   • Clusters of cuboidal or short columnar cells

   • Arranged around a central lumen

3. Homer Wright rosettes：

   • Radial arrangements of cells

   • Around a central tangle of fibrils (pseudorosette)

4. Fleurette: photoreceptor differentiation

5. Necrosis is easily seen

D. Others：

1. Most common malignant eye tumor of childhood

2. Characteristics：

   • Can be multifocal and bilateral

   • May undergo spontaneous regression

   • High incidence of second primary malignancy

   • Common sites of metastasis: CNS, skull, lymph nodes and distal bones

   • Frequently occurs as a congenital tumor

     • Affect both sexes equally

     • 2 patterns: familial vs. sporadic

     • Neuroepithelial origin

E. Reference：

1. Robbins pathologic basis of disease. Ch31. p.1372-1373.

  

 

 

 

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